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c/tapering·submitted 1 year ago by u/taper_off_tabitha

help me understand appetite return, I have read the wiki twice

Trial Databranch of 12 comments

Posting this because I searched for it and got nothing useful. Setup: 7.5mg, week 69, injection-site soreness present but not ruining anything. I changed exactly one variable — appetite return — and tracked it for 10 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else…

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12 comments, started 1 year ago
u/priya_weiss21 points·1 year ago
genuinely useful, thanks
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u/ahmed_okafor15 points·1 year ago

Yeah, regain is not a failure.

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u/malin_petrescu13 points·1 year ago

Small correction: the trial was 21 weeks, not 40. Does not change your point but people will quote it.

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u/source_or_silence10 points·1 year ago

say how long you were on and at what dose before taper

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u/taper_off_tabithaOP5 points·1 year ago

say how long you were on and at what dose before taper

Disagree on that part. 97.4% and 97.6% on the same vial is normal.

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u/teodor_lokken3 points·1 year ago

STEP 1 and SURMOUNT-4 discontinuation arms show regain

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u/cormac_erdogan2 points·1 year ago

Strongly agree. The regain is expected.

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[deleted]1 point·1 year ago

[deleted]

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u/zeynep_ndiaye12 points·1 year ago

Has anyone actually got this in writing, or is it forum lore at this point?

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u/source_or_silence9 points·1 year ago

interval stretching versus dose reduction

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u/neha_krastev11 points·1 year ago

Not convinced. The evidence does not support that reading.

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u/naomi_ekstrom5 points·1 year ago

cite the discontinuation data rather than guessing regain rates

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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