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c/tapering·submitted 12 months ago by u/arne_restrepo

[Discussion] we are measuring discontinuation at the wrong time and calling it noise

Discussionbranch of 7 comments

appetite return. That is the whole post, but I will justify it. Everything else people worry about in c/glp1eu is downstream of it. Titration speed, reflux, the endless dose arguments — most of it resolves if you sort appetite return out first, and almost nobody does. I say this having got it wrong for 21 months. My…

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7 comments, started 12 months ago
u/priya_weiss96 points·12 months ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/careful_gradient75 points·12 months ago·edited

What was the batch number and which service?

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u/meera_oyelaran25 points·12 months ago

regain on taper is expected, plan for it

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u/ilias_nakamura30 points·12 months ago

How many weeks between the two measurements?

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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