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c/tapering·posted 10 months ago by u/vikram_asante

my eGFR moved and I cannot work out whether appetite return is why

Question Receipts ×7 Long Haul ×2

tapering. That is the whole post, but I will justify it.

Everything else people worry about in c/coa is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort tapering out first, and almost nobody does.

I say this having got it wrong for 10 months. My triglycerides was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.

3,172 up / 1,120 down74% upvoted21 commentsid hb8moc19 Sep 2025

21 comments

10 in this archive, depth 5

best — the order this archive was captured in

u/camila_marchand338 points·10 months ago·edited

the regain is treatment of chronic condition ending, not failure

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[deleted]126 points·10 months ago

[deleted]

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u/lane_watchermod · logistics71 points·10 months ago

Strongly agree. The regain is expected.

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u/malin_petrescu45 points·10 months ago

STEP 1 and SURMOUNT-4 discontinuation arms show regain

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u/cormac_roos36 points·10 months ago

appetite return timelines vary regain

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u/rina_bergstrom257 points·10 months ago

Yeah, regain is not a failure.

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u/vikram_asanteOP133 points·10 months ago

The sulphur burps was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/cormac_roos72 points·10 months ago

Small correction: the trial was 16 weeks, not 13. Does not change your point but people will quote it.

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u/taper_off_tabitha193 points·10 months ago

no shaming people who restart

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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