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c/survodutide·submitted 1 months ago by u/tuva_kirchner

[Question] how do you actually verify glucagon

Questionbranch of 8 comments

Quick one. Canada here. MASH works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 24 weeks and cost roughly what I expected. The admin was worse than the cost.…

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8 comments, started 1 months ago
u/zeynep_ndiaye37 points·1 months ago

the MASH indication changes the risk calculus

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u/preservative_free_p13 points·1 months ago

Yeah, glucagon co-agonism is genuinely different.

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u/fibre_forward-16 points·1 months ago

Yeah, glucagon co-agonism is genuinely different.

Yes, exactly this, and it is the bit that took me 66 weeks to accept.

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u/britt_okwuosa1 point·1 months ago

the MASH indication changes the risk calculus

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u/tuva_kirchnerOP1 point·1 months ago

The fatigue was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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[deleted]14 points·1 months ago

[deleted]

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u/injection_site_iris11 points·1 months ago·edited

Slight fix: the number was 97.6, not 97.4. Decimal point, but a fairly consequential one.

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u/incretin_ivypharmacology2 points·1 months ago

the GLP-1/glucagon dual is hepatic fat, different from GIP/GLP-1

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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