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c/survodutide·submitted 2 months ago by u/laila_yilmaz

[Meta] the survodutide rule is doing its job and people should stop complaining

Trial Databranch of 7 comments

Genuinely asking, not being difficult. Everyone in c/intlshipping repeats that biopsy is important. I believe it, but I have never seen anyone show why, and when I search I get 17 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because…

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7 comments, started 2 months ago
u/preservative_free_p-11 points·2 months ago

Stalled for 3 weeks, changed nothing, and it started moving again on week 34.

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[deleted]1 point·2 months ago

[deleted]

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u/kaia_wojcik1 point·2 months ago

Hepatic fat or MASH or what?

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u/yannick_petrov1 point·2 months ago

the MASH indication changes the risk calculus

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u/laila_yilmazOP1 point·2 months ago

Stalled for 3 weeks, changed nothing, and it started moving again on week 26.

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u/coa_janitormod · c/coa1 point·2 months ago

MASH claims need the trial and the biopsy endpoint

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u/laila_yilmazOP1 point·2 months ago

the GLP-1/glucagon dual is hepatic fat, different from GIP/GLP-1

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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