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c/survodutide·posted 2 months ago by u/laila_yilmaz

[Meta] the survodutide rule is doing its job and people should stop complaining

Trial Data Receipts ×7

Genuinely asking, not being difficult.

Everyone in c/intlshipping repeats that biopsy is important. I believe it, but I have never seen anyone show why, and when I search I get 17 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

859 up / 131 down87% upvoted48 commentsid rv8f2e17 May 2026

48 comments

17 in this archive, depth 5

best — the order this archive was captured in

u/preservative_free_p-11 points·2 months ago

Stalled for 3 weeks, changed nothing, and it started moving again on week 34.

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[deleted]1 point·2 months ago

[deleted]

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u/kaia_wojcik1 point·2 months ago

Hepatic fat or MASH or what?

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u/yannick_petrov1 point·2 months ago

the MASH indication changes the risk calculus

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u/laila_yilmazOP1 point·2 months ago

Stalled for 3 weeks, changed nothing, and it started moving again on week 26.

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u/coa_janitormod · c/coa1 point·2 months ago

MASH claims need the trial and the biopsy endpoint

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u/laila_yilmazOP1 point·2 months ago

the GLP-1/glucagon dual is hepatic fat, different from GIP/GLP-1

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u/incretin_ivypharmacology58 points·2 months ago

Phase 20 or 15?

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u/renzo_asante20 points·2 months ago

phase 6 data is interesting, phase 12 will be different

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u/throwaway_wl20266 points·2 months ago

not approved, descriptive posts only

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u/vitamin_d_void1 point·2 months ago

This is correct. Do not generalise from tirzepatide.

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u/chidi_demir14 points·2 months ago

not approved, descriptive posts only

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u/cesar_ivaturi12 points·2 months ago

glucagon co-agonism has a different safety story

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u/laila_yilmaz10 points·2 months ago·edited

Which trial arm?

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u/runa_pires8 points·2 months ago

the GLP-1/glucagon dual is hepatic fat, different from GIP/GLP-1

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u/crosspost_bot_no40 points·2 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/endotoxin_elliemicro16 points·2 months ago

Which trial arm?

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About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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Feb 2024created
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Independent HPLC and mass spec. The number you get is the number they found.

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Custom peptides and amino acids direct from the manufacturer since 1998. ISO 9001 / cGMP. Batch COA every order.

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c/survodutide rules
  1. Glucagon co-agonism has a distinct safety story. Do not generalise from tirzepatide.
  2. MASH claims need the trial and the biopsy endpoint.
  3. Not approved. Descriptive posts only.
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