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c/survodutide·submitted 1 year ago by u/zeynep_ndiaye

6 months in and glucagon is still the thing I get wrong

Questionbranch of 5 comments

Posting this because I searched for it and got nothing useful. Setup: 10mg, week 13, injection-site soreness present but not ruining anything. I changed exactly one variable — hepatic fat — and tracked it for 7 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else…

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5 comments, started 1 year ago
u/liv_vukovic30 points·1 year ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/tired_ledger_ftw20 points·1 year ago

Came off after 53 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/zeynep_ndiayeOP18 points·1 year ago

Maintenance for 13 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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u/throwaway_wl202615 points·1 year ago

Strongly agree. The safety story is separate.

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u/tuva_kirchner4 points·1 year ago

the MASH indication changes the risk calculus

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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