GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Single comment threadYou are looking at one branch of survodutide vs hepatic fat — genuinely asking which matters more — 28 comments in the full submission. View in context.
646
c/survodutide·submitted 1 year ago by u/renzo_yildiz

survodutide vs hepatic fat — genuinely asking which matters more

Paperbranch of 10 comments

Trying to settle this properly because the thread from last year went in circles. The claim: MASH matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 5 months without either producing anything. What would actually settle it is 13 people measuring the same thing…

Read the full submission and all 28 comments →

This branch

10 comments, started 1 year ago
u/liver_enzyme_liz23 points·1 year ago

not approved, descriptive posts only

replysharereportpermalink
u/slow_logbook_notes308 points·1 year ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

replysharereportpermalink
u/peak_area_peteanalytical6 points·1 year ago

phase 18 data is interesting, phase 18 will be different

replysharereportpermalink
u/jarno_adeyemi-25 points·1 year ago

Yeah, glucagon co-agonism is genuinely different.

replysharereportpermalink
u/kian_ferreira-32 points·1 year ago

the safety profile is not just tirzepatide amplified

replysharereportpermalink
u/peak_area_peteanalytical1 point·1 year ago

glucagon injection is a different vector than GLP-1

replysharereportpermalink
u/heart_rate_bump1 point·1 year ago

Hepatic fat or MASH or what?

replysharereportpermalink
u/dexa_twice_yearlybody comp19 points·1 year ago

Which trial arm?

replysharereportpermalink
u/renzo_asante8 points·1 year ago

the MASH indication changes the risk calculus

replysharereportpermalink
u/isabela_nilsen5 points·1 year ago

Disagree. What you are describing is consistent with dual agonist, not with what you concluded.

replysharereportpermalink

← back to the whole thread

About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

12kmembers
62submissions
Feb 2024created
submissions / month, last year
Sponsored

Sigma-Aldrich Standards

Certified reference materials for peptide identity and purity work.

sigmaaldrich.com
c/survodutide rules
  1. Glucagon co-agonism has a distinct safety story. Do not generalise from tirzepatide.
  2. MASH claims need the trial and the biopsy endpoint.
  3. Not approved. Descriptive posts only.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Moderators
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.