stalled for 12 weeks at 1.0mg and I refuse to panic this time
chromatogram. That is the whole post, but I will justify it. Everything else people worry about in c/reconstitution is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort chromatogram out first, and almost nobody does. I say this having got it wrong for 22…
integration decision on a shoulder changes your number by half a point on its own
Strongly agree. Largest single impurity tells a different story than total purity.
related substances are where the story lives, not the main peak
Yeah, the chromatogram profile matters more than the headline number.
Ran the same vial on two columns, different purity, both right, different separation. Method matters more than equipment.
integration decision on a shoulder changes your number by half a point on its own
integration decision on a shoulder changes your number by half a point on its own
Disagree on that part. 93.7% and 99.3% on the same vial is normal.
Slight fix: the number was 99.0, not 98.9. Decimal point, but a fairly consequential one.