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c/hplc·submitted 3 months ago by u/step_count_stan

integration vs purity — genuinely asking which matters more

Methodbranch of 4 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking LC-MS against eGFR for 15 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one assay, no…

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4 comments, started 3 months ago
u/hana_lehtinen14 points·3 months ago

The related substances profile is way more interesting than the main peak %. A 98% with 12 peaks is different from a 98% that is one 34% impurity.

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[deleted]10 points·3 months ago

[deleted]

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u/honest_syringe_pls7 points·3 months ago

This is the correct method framing. Column and gradient are load-bearing fields.

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u/canada_coverage10 points·3 months ago

chromatogram or it did not happen

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