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c/survodutide·posted 9 months ago by u/whois_wanda

Denmark: dual agonist, and what it actually costs here

Trial Data Sourced ×4

Been lurking in c/t2dglp1 for about 9 months and finally have something worth posting.

Short version: week 26, 0.25mg, and hepatic fat is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 29 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 20.

903 up / 293 down76% upvoted31 commentsid vh9k2z21 Oct 2025

31 comments

22 in this archive, depth 6

best — the order this archive was captured in

u/trialwatch_theoMOD152 points·9 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/vikram_mbeki71 points·9 months ago·edited

the safety profile is not just tirzepatide amplified

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u/zeynep_ndiaye99 points·9 months ago

the safety profile is not just tirzepatide amplified

Adding to this: dual agonist is doing more work than the comment implies.

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u/whois_wandaOP-24 points·9 months ago

the MASH indication changes the risk calculus

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u/vitamin_d_void1 point·9 months ago

do not generalise from tirzepatide

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u/dexa_twice_yearlybody comp1 point·9 months ago

Yeah, glucagon co-agonism is genuinely different.

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u/diego_szabo56 points·9 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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[deleted]23 points·9 months ago

[deleted]

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u/chidi_demir96 points·9 months ago

This is correct. Do not generalise from tirzepatide.

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u/tomas_lokken56 points·9 months ago

Australia here. Waited 9 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/teodor_szabo44 points·9 months ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/crosspost_bot_no26 points·9 months ago

Yeah, glucagon co-agonism is genuinely different.

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u/certified_referenceQC30 points·9 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/quant_not_qual24 points·9 months ago·edited

the safety profile is not just tirzepatide amplified

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u/samir_falk14 points·9 months ago

I am going to push back on this slightly.

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u/rania_marchand7 points·9 months ago

the GLP-1/glucagon dual is hepatic fat, different from GIP/GLP-1

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u/annika_fonseca22 points·9 months ago

glucagon co-agonism has a different safety story

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u/endotoxin_elliemicro55 points·9 months ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/isabela_nilsen44 points·9 months ago·edited

do not generalise from tirzepatide

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u/elin_tamm13 points·9 months ago

Hepatic fat or MASH or what?

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u/milos_mensa9 points·9 months ago

Strongly agree. The safety story is separate.

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u/marisol_frisk5 points·9 months ago

the GLP-1/glucagon dual is hepatic fat, different from GIP/GLP-1

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About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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