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c/survodutide·submitted 1 months ago by u/britt_abubakar

stalled for 9 weeks at 12.5mg and I refuse to panic this time

Cautionbranch of 6 comments

Genuinely asking, not being difficult. Everyone in c/tirzepatide repeats that biopsy is important. I believe it, but I have never seen anyone show why, and when I search I get 17 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because…

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6 comments, started 1 months ago
u/chidi_demir8 points·1 months ago·edited

This is correct. Do not generalise from tirzepatide.

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u/britt_abubakarOP6 points·1 months ago

Phase 9 or 36?

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u/lina_ndiaye4 points·1 months ago

Disagree. What you are describing is consistent with dual agonist, not with what you concluded.

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u/annika_fonseca0 points·1 months ago

the GLP-1/glucagon dual is glucagon, different from GIP/GLP-1

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u/tuva_kirchner0 points·1 months ago

phase 14 data is interesting, phase 35 will be different

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u/andres_dahlberg1 point·1 months ago

MASH claims need the trial and the biopsy endpoint

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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