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c/survodutide·submitted 1 months ago by u/kaia_kuusela

[Discussion] glucagon is doing more work than we give it credit for

Discussionbranch of 4 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking survodutide against ApoB for 25 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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4 comments, started 1 months ago
u/annika_fonseca11 points·1 months ago

Strongly agree. The safety story is separate.

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u/kaia_kuuselaOP8 points·29 days ago

phase 13 data is interesting, phase 14 will be different

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u/preservative_free_p7 points·1 months ago

Strongly agree.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/clara_restrepo10 points·29 days ago

rodent dual agonist is investigation only

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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