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c/survodutide·posted 2 years ago by u/nora_ramos

[Question] glucagon — what am I missing here

Question Cold Box ×4 The Quiet One ×2

Been lurking in c/t2dglp1 for about 23 months and finally have something worth posting.

Short version: week 57, 2.5mg, and hepatic fat is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 3 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 51.

2,069 up / 388 down84% upvoted13 commentsid qr6usj12 Mar 2024

13 comments

7 in this archive, depth 3

best — the order this archive was captured in

u/chidi_demir189 points·2 years ago

Stalled for 13 weeks, changed nothing, and it started moving again on week 24.

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[removed]71 points·2 years ago

[removed by moderator]

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u/honest_syringe_pls59 points·2 years ago

hepatic fat and survodutide are the story

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u/elin_tamm156 points·2 years ago

Australia here. Waited 9 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/camila_trevino47 points·2 years ago·edited

hepatic fat and survodutide are the story

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u/valeria_karlsen118 points·2 years ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/joaquin_ivaturi209 points·2 years ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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