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c/survodutide·posted 4 months ago by u/paper_trail_paula

am I the only one who found biopsy harder than the injections

Question Long Haul ×8 Sourced ×3

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking survodutide against eGFR for 15 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

1,016 up / 48 down95% upvoted20 commentsid 1wnvgj31 Mar 2026

20 comments

13 in this archive, depth 4

best — the order this archive was captured in

u/elin_tamm-37 points·4 months ago
no
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u/paper_trail_paulaOPvetting1 point·4 months ago

Spain here. Waited 13 months on a list, gave up, went private, and the total cost was roughly what I expected.

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u/incretin_ivypharmacology95 points·4 months ago

the MASH indication changes the risk calculus

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u/honest_syringe_pls51 points·3 months ago

Yeah, glucagon co-agonism is genuinely different.

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u/endotoxin_elliemicro77 points·4 months ago

Not convinced. The evidence does not support that reading.

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u/nora_oyelaran17 points·3 months ago

phase 13 data is interesting, phase 26 will be different

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u/protein_first_pnutrition4 points·3 months ago

the MASH indication changes the risk calculus

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u/paper_trail_paulaOPvetting2 points·3 months ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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u/julia_mensa36 points·3 months ago

Not convinced.

Disagree on that part. 97.4% and 97.6% on the same vial is normal.

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u/injection_site_iris60 points·4 months ago

the heart rate signal is real in the data

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u/milan_mensah21 points·4 months ago

the heart rate signal is real in the data

Yes, exactly this, and it is the bit that took me 5 weeks to accept.

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u/fibre_forward28 points·4 months ago

the heart rate signal is real in the data

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u/paper_trail_paulaOPvetting17 points·4 months ago

Maintenance for 3 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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About c/survodutide

Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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