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c/survodutide·submitted 1 year ago by u/nora_oyelaran

[Meta] proposal — a flair for survodutide posts

Paperbranch of 7 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking survodutide against eGFR for 21 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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7 comments, started 1 year ago
u/sofia_danquah90 points·1 year ago

Not convinced. The evidence does not support that reading.

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u/incretin_ivypharmacology54 points·1 year ago

glucagon co-agonism has a different safety story

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[removed]40 points·1 year ago

[removed by moderator]

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u/britt_abubakar-23 points·1 year ago

You have restated the marketing copy. What is the actual substance here.

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u/kaia_cabrera1 point·1 year ago

I am going to push back on this slightly.

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u/clara_restrepo1 point·1 year ago

the heart rate signal is real in the data

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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