three years of chromatogram threads, summarised so you do not have to read them
chromatogram. That is the whole post, but I will justify it. Everything else people worry about in c/dosinglogs is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort chromatogram out first, and almost nobody does. I say this having got it wrong for 19…
Strongly agree. Largest single impurity tells a different story than total purity.
Strongly agree.
Adding to this: HPLC is doing more work than the comment implies.
the detector wavelength matters more than people think
Ran the same vial on two columns, different purity, both right, different separation. Method matters more than equipment.
Strongly agree.
Adding to this: HPLC is doing more work than the comment implies.
area% and mass% are not the same and this whole post conflates them
Strongly agree.
Yes, exactly this, and it is the bit that took me 41 weeks to accept.