three years of chromatogram threads, summarised so you do not have to read them
chromatogram. That is the whole post, but I will justify it. Everything else people worry about in c/dosinglogs is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort chromatogram out first, and almost nobody does. I say this having got it wrong for 19…
Strongly agree. Largest single impurity tells a different story than total purity.
Not to be pedantic but LC-MS and chromatogram are being used interchangeably and they are not interchangeable in real life.
area% and mass% are not the same and this whole post conflates them
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
No.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.