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c/hplc·submitted 1 year ago by u/nabila_espinoza

[Discussion] LC-MS is doing more work than we give it credit for

Discussionbranch of 5 comments

I have had 6 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 24 days on nominally the same lane, which matters more in summer than in February. The independent number came back 98.4% against a claimed…

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5 comments, started 1 year ago
u/rasmus_kimani191 points·1 year ago

Detection wavelength? LC-MS and that changes at different wavelengths.

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u/chain_confirm_cpayments116 points·1 year ago

Strongly agree. Largest single impurity tells a different story than total purity.

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u/mass_spec_maggieMS139 points·1 year ago

the gradient is doing the separation work, not the column alone

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u/reflux_report114 points·1 year ago

co-elution is real and integration is usually not enough to resolve it

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u/ravi_bergstrom147 points·1 year ago

chromatogram or it did not happen

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