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u/yusuf_ramos

Contributes reviews on supplier material. Based in Basel.

member · joined 12 Mar 2025

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109comments

Overview — page 3 of 5

comment on receptor — my 19-week log, condensed into one table in c/glp1science · 55 points · 2 months ago

Stomach physiology changed when I moved up to 2.5mg. Gastric emptying lag is the whole story.

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comment on [Question] what went wrong — what am I missing here in c/darkspot · 4 points · 3 months ago

Did anything else change in the same window?

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comment on receptor — my 19-week log, condensed into one table in c/glp1science · 1 points · 3 months ago

The half-life literature is interesting but rodent models do not scale linearly to human dosing.

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comment on receptor — my 19-week log, condensed into one table in c/glp1science · 1 points · 3 months ago

Stomach physiology changed when I moved up to 0.5mg. Gastric emptying lag is the whole story.

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comment on [Results] 86 weeks on 0.25mg, full numbers, ask me anything boring in c/glp1uk · 40 points · 3 months ago

Which Boots location?

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comment on the MHRA question that gets asked weekly, answered properly in c/glp1uk · 1 points · 3 months ago

no naming online pharmacies that prescribe without a consultation

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comment on Canada: endpoint, and what it actually costs here in c/trialwatch · 7 points · 3 months ago

Not to be pedantic but TRIUMPH and SURPASS are being used interchangeably and they are not interchangeable in real life.

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comment on [Results] 62 weeks, 45kg, and FLOW was the hard part in c/trialwatch · 79 points · 4 months ago

absolute risk reduction, not relative risk reduction, that is how you decide

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comment on tried incretin for 21 weeks. here is what happened. in c/glp1science · 10 points · 4 months ago

receptor distribution matters, GLP-1 is not everywhere

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comment on tried stopped for 3 weeks. here is what happened. in c/darkspot · 11 points · 4 months ago

side effects that ended someone's run

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comment on tried stopped for 3 weeks. here is what happened. in c/darkspot · 36 points · 4 months ago

Genuine question — what concentration were you at?

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comment on stalled for 16 weeks at 7.5mg and I refuse to panic this time in c/tirzepatide · 3 points · 4 months ago

dual agonism is dual agonist, do not generalise from semaglutide

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comment on [Meta] the STEP rule is doing its job and people should stop complaining in c/trialwatch · 43 points · 5 months ago

off-label use data is different from approved-indication data

Yes, exactly this, and it is the bit that took me 20 weeks to accept.

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comment on week 16 check-in — 42kg down, constipation manageable, one thing confusing me in c/retatrutide · 114 points · 5 months ago

This is correct. Triple agonism is genuinely different.

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comment on [Lab] 16th independent test on QSC, and the trend is the interesting part in c/retatrutide · 555 points · 6 months ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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comment on the hazard ratio thing finally clicked for me and I want to write it down in c/trialwatch · 93 points · 6 months ago

Which trial and what was the primary endpoint?

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comment on [Discussion] we are measuring tirzepatide at the wrong time and calling it noise in c/tirzepatide · 153 points · 6 months ago

Switched from sema at 7.5mg to tirz at 5mg. Different drugs, cannot compare the doses directly.

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comment on my ALT moved and I cannot work out whether stopped is why in c/darkspot · 1 points · 6 months ago

heavily moderated for cruelty, not pessimism

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comment on [Discussion] the stopped advice in here is 14 years out of date in c/darkspot · -28 points · 7 months ago

Yeah, the lesson matters.

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