u/yara_bakken
Contributes reviews on supplier material. Based in Recife.
member · joined 12 Mar 2025
comment on FLOW got published and nobody in here is talking about eGFR slope in c/trialwatch · 8 points · 1 days ago
phase 2 is not phase 3, smaller n and shorter trial
comment on [Readout] SELECT: MACE HR 0.80, and the absolute numbers people skip in c/trialwatch · 3 points · 2 days ago
You have restated the marketing copy. What is the actual substance here.
comment on [Method] the gradient everyone uses for sema and why it under-resolves the des-amido in c/hplc · 9 points · 4 days ago
state the method: column, gradient, detection wavelength, injection volume
comment on [Method] the gradient everyone uses for sema and why it under-resolves the des-amido in c/hplc · 19 points · 4 days ago
related substances are where the story lives, not the main peak
comment on [Method] the gradient everyone uses for sema and why it under-resolves the des-amido in c/hplc · 6 points · 4 days ago
This is the correct method framing. Column and gradient are load-bearing fields.
comment on [Trial Data] STEP 1 vs SURMOUNT-1 side by side, with the caveats in c/trialwatch · 1 points · 5 days ago
the discontinuation arms are the interesting part, not the endpoint endpoints
comment on [Paper] ATTAIN-1 — an oral pill with no food restrictions is a bigger deal than the % suggests in c/trialwatch · 28 points · 15 days ago
dropout handling matters, especially on GI-heavy populations
comment on integration vs method development — genuinely asking which matters more in c/hplc · 1 points · 24 days ago
integration decision on a shoulder changes your number by half a point on its own
comment on method development — 10 things I got wrong before I got it right in c/hplc · 14 points · 26 days ago
comment on interval stretching is the most under-discussed thing in c/t2dglp1 in c/tapering · 12 points · 1 months ago
the people who came off and restarted without shame
comment on small win: TRIUMPH stopped being a problem at week 15 in c/trialwatch · 35 points · 1 months ago
Not convinced. The evidence does not support that reading.
comment on small win: TRIUMPH stopped being a problem at week 15 in c/trialwatch · 95 points · 1 months ago
Small correction: the trial was 18 weeks, not 14. Does not change your point but people will quote it.
comment on [Question] method development — what am I missing here in c/hplc · 2 points · 3 months ago
Injection volume and flow rate? Those affect resolution.
comment on Medutest — 2 things I got wrong before I got it right in c/labresults · 41 points · 3 months ago
CPC claimed 98.4%, VendorInvestigate came back 95.1%.
Yes, exactly this, and it is the bit that took me 14 weeks to accept.
comment on [Results] 87 weeks, 11kg, and interval stretching was the hard part in c/tapering · 75 points · 3 months ago
tapering instructions are not welcome here
comment on switched from 1.0mg to 0.5mg and the sulphur burps got better, not worse in c/hplc · 79 points · 3 months ago
Crossposting this to c/progresspics because the people who need it are not reading this community.
comment on am I the only one who found test results harder than the injections in c/labresults · 63 points · 3 months ago
Strongly agree. Below-spec results matter as much as good ones.
comment on interval stretching is the most under-discussed thing in c/compounding in c/tapering · 1 points · 4 months ago
cite the discontinuation data rather than guessing regain rates
Adding to this: interval stretching is doing more work than the comment implies.
comment on France: chromatogram, and what it actually costs here in c/hplc · 87 points · 4 months ago
Sceptical. If this were true we would see it reflected in the data and we do not.
comment on week 76 check-in — 31kg down, muscle cramps manageable, one thing confusing me in c/tapering · 98 points · 5 months ago
STEP 1 and SURMOUNT-4 discontinuation arms show regain