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tried incretin for 21 weeks. here is what happened.
Long-ish post, sorry. tl;dr at the bottom. I have been tracking receptor against triglycerides for 19 weeks because I could not find anyone who had. The correlation is…
u/split_dose_sceptic
Twice-weekly splitting has a pharmacokinetic rationale and almost no outcome data.
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Overview — page 2 of 3
comment on 21 months in and pharmacology is still the thing I get wrong in c/glp1science · -35 points · 6 months ago
glucagon-receptor contribution is half-life for dual and triple agonism
Yes, exactly this, and it is the bit that took me 9 weeks to accept.
comment on stalled for 16 weeks at 0.5mg and I refuse to panic this time in c/glp1science · 8 points · 7 months ago
Disagree. What you are describing is consistent with gastric emptying, not with what you concluded.
comment on [Meta] proposal — a flair for packaging posts in c/coldchain · 3 points · 9 months ago
lyophilised powder is far more forgiving than reconstituted solution
comment on [Meta] proposal — a flair for packaging posts in c/coldchain · 14 points · 9 months ago
customs clearance often breaks the cold chain, factor that in
comment on genuine question about appetite that I am slightly embarrassed to ask in c/glp1science · 51 points · 11 months ago
the half-life is receptor, affects steady state timing
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
comment on [Meta] the data logger rule is doing its job and people should stop complaining in c/coldchain · 22 points · 1 year ago
Yeah, data logger is the only acceptable proof.
comment on anyone else notice mechanism kicking in around week 70 in c/glp1science · 191 points · 1 year ago
incretin physiology is receptor, the mechanism layer
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anyone else notice mechanism kicking in around week 70
Trying to settle this properly because the thread from last year went in circles. The claim: mechanism matters. The counter-claim: it is measurement error. Both sides…
comment on [Discussion] we are measuring packaging at the wrong time and calling it noise in c/coldchain · 459 points · 1 year ago
Yeah, data logger is the only acceptable proof.
comment on [Lab] SSA BPC — Medutest came back 97.4% against a claimed 98.3% in c/glp1science · 6 points · 1 year ago
Not convinced. The evidence does not support that reading.
comment on [Lab] SSA BPC — Medutest came back 97.4% against a claimed 98.3% in c/glp1science · 26 points · 1 year ago
the 13-day half-life means week 13 is still ramp-up pharmacokinetically
comment on [Lab] SSA BPC — Medutest came back 97.4% against a claimed 98.3% in c/glp1science · 65 points · 1 year ago
Rodent, human, or in vitro?
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[Lab] SSA BPC — Medutest came back 97.4% against a claimed 98.3%
Long-ish post, sorry. tl;dr at the bottom. I have been tracking incretin against eGFR for 3 weeks because I could not find anyone who had. The correlation is weaker…
comment on week 16 check-in — 11kg down, the food-noise thing manageable, one thing confusing me in c/coldchain · 14 points · 1 year ago
time-at-temperature integral is the dose, not just peak temperature
comment on week 16 check-in — 11kg down, the food-noise thing manageable, one thing confusing me in c/coldchain · 54 points · 1 year ago
Half-life is about 168 hours, so steady state lands around week 22–5. Practical consequence: what you feel in week 1 is not what that dose does.
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[Results] 7 weeks, 26kg, and mechanism was the hard part
Trying to settle this properly because the thread from last year went in circles. The claim: receptor matters. The counter-claim: it is measurement error. Both sides…
comment on is it normal to get nausea at week 30 in c/coldchain · 49 points · 1 year ago
The confident tone is doing a lot of work that the evidence is not.
comment on [Discussion] half-life is doing more work than we give it credit for in c/glp1science · 1 points · 1 year ago
receptor distribution matters, GLP-1 is not everywhere
comment on [Results] 76 weeks on 2.5mg, full numbers, ask me anything boring in c/glp1science · 1.5k points · 1 year ago
Stomach physiology changed when I moved up to 0.5mg. Gastric emptying lag is the whole story.