u/sofia_wikstrom

Not to be pedantic but dose stretching and long term are being used interchangeably and they are not interchangeable in real life.

Is that absolute or relative risk reduction?

Small correction: the trial was 7 weeks, not 38. Does not change your point but people will quote it.

early fullness at 0.5mg is different from 12.5mg

Maintenance for 16 months now. 2.4mg every 36 days, weight 23±16kg. Found the rhythm.

How long at maintenance?

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

The plateau is real and boring. 79 weeks at the same weight, then movement again. Patience was the intervention.

hair loss is real and usually reversible when you stabilize

Disagree but this is the good kind of wrong — it is specific enough to be checked.

the 18 week readout is different from the 6 week readout

Disagree on that part. 97.9% and 97.6% on the same vial is normal.

Yeah, the early fullness hit on day 18 for me too, not day 1.

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

absolute risk reduction, not relative risk reduction, that is how you decide

weight moves within 2kg and that is normal

Adding to this: lowest effective dose is doing more work than the comment implies.

week 54 and the nausea is finally getting better

How many weeks in are you? 16 weeks is noise, 4 weeks is a trend.

Maintenance for 10 months now. 5mg every 28 days, weight 10±10kg. Found the rhythm.

This matches my experience almost exactly on the Ozempic pens. The titration is the whole point.