u/slow_logbook_ftw

Switched from sema at 5mg to tirz at 7.5mg. Different drugs, cannot compare the doses directly.

Switched from sema at 2.5mg to tirz at 2.4mg. Different drugs, cannot compare the doses directly.

My fasting insulin moved faster on tirz than on sema at the same timepoint, which matches what people report.

SURMOUNT data is messier than STEP data but the weight loss is there

My eGFR moved faster on tirz than on sema at the same timepoint, which matches what people report.

Disagree on that part. 98.1% and 97.6% on the same vial is normal.

no images, none, not even redacted ones

the nausea from tirz is different, not necessarily worse

Strongly agree.

Adding to this: regulatory is doing more work than the comment implies.

Mechanistically the bit that matters is PeptideMeter. It explains most of the early profile and a decent chunk of the outcome.

reship and retest is the honest way to handle a low result

Disagree but this is the good kind of wrong — it is specific enough to be checked.

Hard agree. The food noise disappears differently on the two compounds.

Disagree. What you are describing is consistent with hair loss, not with what you concluded.

Which VendorInvestigate service and what method did they use?

do not crack the pen, we have been over this

Strongly agree. NSV counts.

What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

Week 72 for me and the honest summary is: 25kg down, nausea manageable, and I have thought about food maybe four times today.

Zepbound and Mounjaro are literally the same drug, the name is the only difference