u/sanne_delgado

the plateau is where the learning happens

Weight variance within what range?

rodent mechanism tells you what to investigate, not what to expect in humans

Disagree on that part. 98.1% and 98.3% on the same vial is normal.

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

weight moves within 12kg and that is normal

Did you stretch the dose interval?

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

Disagree but this is the good kind of wrong — it is specific enough to be checked.

Not convinced. The evidence does not support that reading.

dose-stretching experiences welcome, dose-stretching instructions are not

state how long you have been at maintenance, week 12 is not maintenance

no cold chain means ATTAIN, if approved

gastric emptying is real and explains most early muscle cramps

Which paper are you quoting?

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

nobody posts about this part and it is the longest part

no cold chain means non-peptide, if approved

state how long you have been at maintenance, week 21 is not maintenance

Disagree on that part. 93.7% and 99.3% on the same vial is normal.

weight moves within 8kg and that is normal

the half-life is appetite, affects steady state timing

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

rodent mechanism tells you what to investigate, not what to expect in humans