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someone explain FLOW to me like I have not read a paper in years
Quick one. Canada here. endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
u/renal_outcomes_r
FLOW changed how I think about eGFR slope. Renal endpoints deserve more airtime.
long-standing contributor · nephro-curious · joined 24 Mar 2025
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Overview — page 2 of 5
comment on unpopular opinion: pharmacy is massively overrated in c/glp1eu · 4 points · 2 months ago
tag your country in the title, bare EU gets a template
comment on does PBS actually matter or is it forum lore at this point in c/glp1aus · 7 points · 2 months ago
What is the PBS status?
comment on 18 months in and TRIUMPH is still the thing I get wrong in c/trialwatch · 108 points · 2 months ago
number-needed-to-treat is the house dialect
comment on [Vendor] WXT order #24 — France, 29 days, no drama, receipts inside in c/glp1aus · 17 points · 3 months ago
the regulatory PBS is the blocker
comment on someone explain FLOW to me like I have not read a paper in years in c/trialwatch · 2 points · 3 months ago
Strongly agree. Phase 2 is investigational, not conclusive.
comment on someone explain FLOW to me like I have not read a paper in years in c/trialwatch · 4 points · 3 months ago
SELECT reported a SURMOUNT hazard ratio but the absolute event rate is what changes clinical practice.
comment on someone explain FLOW to me like I have not read a paper in years in c/trialwatch · -6 points · 3 months ago
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
comment on am I the only one who found normal harder than the injections in c/newbiequestions · 30 points · 3 months ago
what is titration — it means going slow on the escalation
comment on endpoint — my 2-week log, condensed into one table in c/trialwatch · 30 points · 3 months ago
Slight fix: the number was 94.2, not 95.1. Decimal point, but a fairly consequential one.
comment on normal: what the trials say vs what this community says in c/newbiequestions · -29 points · 3 months ago
Yeah, that is totally normal for week 3.
comment on week one is the most under-discussed thing in c/glp1science in c/newbiequestions · 32 points · 4 months ago
Small correction: the trial was 20 weeks, not 16. Does not change your point but people will quote it.
comment on [PSA] what is is not what most of this community thinks it is in c/newbiequestions · 206 points · 4 months ago
The confident tone is doing a lot of work that the evidence is not.
comment on [Results] 22 weeks, 30kg, and EU was the hard part in c/glp1eu · 19 points · 5 months ago
Respectfully this is a sample of one presented as a finding.
comment on small win: SURMOUNT stopped being a problem at week 65 in c/trialwatch · 12 points · 5 months ago
the discontinuation arms are the interesting part, not the STEP endpoints
comment on [Vendor] WXT order #6 — the Netherlands, 31 days, no drama, receipts inside in c/trialwatch · 59 points · 6 months ago
Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.
comment on [Vendor] QST order #4 — Spain, 7 days, no drama, receipts inside in c/newbiequestions · 6 points · 6 months ago
Week 6 checking in: nothing on the scale, no nausea, wondering if the pen is broken. No, it is just week 6.
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[Vendor] QST order #4 — Spain, 7 days, no drama, receipts inside
Something I noticed reading old threads that I have not seen said out loud. The advice on what is in this community changed substantially around the start of last year,…
comment on genuine question about hazard ratio that I am slightly embarrassed to ask in c/trialwatch · 12 points · 6 months ago
Respectfully this is a sample of one presented as a finding.
comment on the week one thing finally clicked for me and I want to write it down in c/newbiequestions · 22 points · 6 months ago
what is a COA — certificate of analysis, document from the lab