u/receptor_bias_rick
Biased agonism is real and mostly irrelevant to your dose. Mostly.
member · joined 19 Aug 2024
Comments — page 2 of 3
comment on 503A — 12 things I got wrong before I got it right in c/compounding · 65 points · 9 months ago
This is the "correlation is mechanism" thing again. You changed three variables at once.
comment on week 56 check-in — 12kg down, injection-site soreness manageable, one thing confusing me in c/coa · 16 points · 9 months ago
That is net peptide content, not purity. Different number, different meaning.
comment on FLOW vs TRIUMPH — genuinely asking which matters more in c/trialwatch · 2 points · 9 months ago
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
comment on what would you tell week-1 you about SURMOUNT in c/trialwatch · 965 points · 10 months ago
press release SELECT posts must be flaired until a publication exists
comment on [Question] timeframe — what am I missing here in c/progresspics · 8 points · 1 year ago
text removes the comparison trap
comment on [Vendor] WXT order #20 — France, 9 days, no drama, receipts inside in c/trialwatch · 48 points · 1 year ago
give the trial name, phase, n, and primary endpoint in the body
comment on switched from 1.7mg to 1.0mg and the fatigue got better, not worse in c/coa · 46 points · 1 year ago
purity and net content are two different numbers, same vial
comment on [Vendor] WXT order #17 — Germany, 5 days, no drama, receipts inside in c/progresspics · 16 points · 1 year ago
text only is the whole point of the community
comment on the COA question that gets asked weekly, answered properly in c/coa · 25 points · 1 year ago
chromatogram or it did not happen
comment on stalled for 23 weeks at 5mg and I refuse to panic this time in c/coa · 441 points · 1 year ago
Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.
comment on three years of 503A threads, summarised so you do not have to read them in c/compounding · 18 points · 1 year ago
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
comment on [Results] 72 weeks, 15kg, and API source was the hard part in c/compounding · 8 points · 1 year ago
the shortage list is temporary, it ends and compounding becomes illegal again
comment on [Discussion] can we stop arguing about endpoint until somebody posts a number in c/trialwatch · 156 points · 1 year ago
Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.
comment on [Question] batch — what am I missing here in c/coa · 6 points · 1 year ago
Half-life is about 168 hours, so steady state lands around week 8–5. Practical consequence: what you feel in week 1 is not what that dose does.
comment on [Discussion] can we stop arguing about telehealth until somebody posts a number in c/compounding · 51 points · 1 year ago
regulatory claims need a citation to the actual rule, not interpretation
comment on my TSH moved and I cannot work out whether API source is why in c/compounding · 39 points · 1 year ago
The 503A pharmacy I used lost their shortage list eligibility. Same day, compounding became illegal. Rules are real.
comment on reading batch threads from 2024 and half of it aged badly in c/coa · 231 points · 1 year ago
Slight fix: the number was 97.4, not 97.2.
Yes, exactly this, and it is the bit that took me 68 weeks to accept.
comment on [Meta] the progress rule is doing its job and people should stop complaining in c/progresspics · 4 points · 1 year ago
no commenting on anybody's body, comment on the process
comment on batch — my 10-week log, condensed into one table in c/coa · 0 points · 2 years ago
comment on the milestone thing finally clicked for me and I want to write it down in c/progresspics · 106 points · 2 years ago
the milestone change matters as much as the scale