u/osman_eriksen

the 10 week discontinuation arm is the data

Disagree but this is the good kind of wrong — it is specific enough to be checked.

central appetite signalling is real but people overweight it

cite the paper: journal, year, first author, links optional

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

private 0.5mg is MHRA in Denmark this month

do not extrapolate rodent data to human dosing without saying so

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

A1c moves slowly, quarterly is plenty

rodent pharmacology tells you what to investigate, not what to expect in humans

The confident tone is doing a lot of work that the evidence is not.

gel packs last 24 hours, after that you are relying on the box itself

The gel pack lasted 20 hours in a courier van, then liquid. Powder itself fine, the cold chain mostly died in transit.

The gel pack lasted 19 hours in a courier van, then liquid. Powder itself fine, the cold chain mostly died in transit.

ApoB over LDL-C, that is the hierarchy

controversial sort brought me here and it was worth it

Adding to this: ApoB is doing more work than the comment implies.

Same lab both times?

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

pharmacy stock is private prescription, check before traveling

Sceptical. If this were true we would see it reflected in the data and we do not.