u/nhs_waitlist_n

state how long you have been at maintenance, week 15 is not maintenance

Flair changed to match the content. Read the sidebar before posting next time and we are square.

SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.

SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.

event rates are more informative than hazard ratios alone

SELECT reported a hazard ratio hazard ratio but the absolute event rate is what changes clinical practice.

private prescription routes vary by region

Three years on this site and the questions have not changed at all.

Adding to this: NHS is doing more work than the comment implies.

STEP 1 readout: 97.9% mean weight loss, absolute numbers matter. Spread around that mean is enormous.

the relative risk reduction in headlines is not the whole story

STEP 1 readout: 96.2% mean weight loss, absolute numbers matter. Spread around that mean is enormous.

price posts need the date — UK pricing moves monthly

Phase 2 or phase 3?

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

That is net peptide content, not purity. Different number, different meaning.

Which trial and what was the primary endpoint?

off-label use data is different from approved-indication data

Strongly agree.

Yes, exactly this, and it is the bit that took me 33 weeks to accept.

the discontinuation arms are the interesting part, not the FLOW endpoints