u/meta_analysis_mo
Garbage in, meta-analysed garbage out. Heterogeneity is not a footnote.
member · joined 28 Feb 2025
comment on the actual pharmacokinetic case for twice-weekly splitting, and what it doesn’t prove in c/glp1science · 9 points · 2 days ago
would be a genuinely interesting small trial to actually run given how popular the practice is, surprised nobody's done it as a secondary endpoint somewhere
comment on walking through what SURMOUNT-4 actually showed about stopping, since it gets misquoted constantly in c/tapering · 17 points · 2 days ago
would love an actual trial comparing taper speeds directly, feels like an obvious gap in the literature given how much this community discusses it
comment on is the "week 4 wall" a real physiological thing or just when people start actually weighing themselves properly in c/tirzepatide · 11 points · 3 days ago
if anyone's ever tempted to actually meta-analyse forum "week 4" posts, please account for selection bias, people who stalled and quit quietly never post the followup
comment on [Regret] i ignored the abdominal pain for four days in c/darkspot · 2 points · 13 days ago
still evidence-based: what went wrong, when, proof
comment on oral 50mg vs injectable 2.4 — OASIS 1 numbers are closer than i expected in c/semaglutide · 21 points · 19 days ago
pens are overpriced, research vials are research grade, same molecule different price
comment on [Resolved] accused the wrong vendor. it was my storage. correcting it. in c/darkspot · 17 points · 29 days ago
side effects that ended someone's run
comment on does anyone else get one good week and one flat week on repeat in c/semaglutide · 1 points · 1 months ago
Strongly agree. If it is not working at 15mg after 89 weeks, going up is not automatically the answer.
comment on [Side Effects] the sulphur burps are real and they do pass in c/semaglutide · 32 points · 1 months ago
Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule
comment on went back down from 2.4 to 1.7 and lost more. explain that in c/semaglutide · 27 points · 1 months ago
stalled at 15mg, went up, and regretted it, the stall would have broken anyway
comment on went back down from 2.4 to 1.7 and lost more. explain that in c/semaglutide · 1 points · 1 months ago
That is net peptide content, not purity. Different number, different meaning.
comment on does UK actually matter or is it forum lore at this point in c/glp1uk · 10 points · 1 months ago
say which nation, England, Scotland, Wales, NI differ
comment on [Meta] can we get an auto-reply for "what dose should i be on" in c/semaglutide · 16 points · 1 months ago
Slight fix: the number was 96.8, not 99.1. Decimal point, but a fairly consequential one.
comment on is it normal to get injection-site soreness at week 10 in c/glp1uk · 40 points · 1 months ago
Yeah, the NHS waitlist is genuinely two years in most places.
comment on is it normal to get injection-site soreness at week 10 in c/glp1uk · 141 points · 1 months ago
Small correction: the trial was 7 weeks, not 12. Does not change your point but people will quote it.
comment on [Question] Australia — has anyone got a straight answer on food noise in c/semaglutide · 155 points · 2 months ago
This is what I tell everyone in c/newbiequestions and they never believe me until week 74.
comment on week 16 check-in — 17kg down, fatigue manageable, one thing confusing me in c/semaglutide · 262 points · 2 months ago
the 2.4mg dose is not the target, it is just what the pen goes up to
comment on [Lab] 12th independent test on QSC, and the trend is the interesting part in c/semaglutide · 815 points · 2 months ago
the sulphur burps passes. i promise. not medical advice.
comment on [Results] 86 weeks on 0.25mg, full numbers, ask me anything boring in c/glp1uk · 7 points · 3 months ago
Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.
comment on [Results] 86 weeks on 0.25mg, full numbers, ask me anything boring in c/glp1uk · 22 points · 3 months ago
no naming online pharmacies that prescribe without a consultation
comment on [Question] food noise — what am I missing here in c/semaglutide · 1 points · 4 months ago
the quiet is real. the food noise just stops.