u/incretin_ivy
GIP/GLP-1 co-agonism is genuinely interesting pharmacology, separate from the weight story.
long-standing contributor · pharmacology · joined 8 Jul 2024
Comments — page 2 of 5
comment on [Discussion] should this community stop using the word "relapse" for regain at all in c/tapering · 154 points · 3 days ago
as someone who thinks about the biology side of this a lot: the mechanistic reality (appetite regulation returning to a prior set point once the drug effect fades) genuinely doesn't map well onto "relapse", which implies a choice or a slip. I'd support moving away from it, though I recognize changing community language is hard and slow.
comment on [Caution] this is not approved anywhere and half this community forgets that in c/retatrutide · 33 points · 3 days ago
Respectfully this is a sample of one presented as a finding.
comment on [Discussion] should this community stop using the word "relapse" for regain at all in c/tapering · 38 points · 3 days ago
that's a fair point and nobody in this thread suggested banning the word for self-description, just suggesting "regain" as the community's default framing rather than "relapse" as the assumed default
comment on is the "week 4 wall" a real physiological thing or just when people start actually weighing themselves properly in c/tirzepatide · 156 points · 4 days ago
bit of both honestly. there's a real pharmacological piece — you're often still mid-titration around week 4-8, and the biggest satiety effects can lag the biggest dose increases by a couple weeks. but there's also a huge measurement-noise piece layered on top, and most people can't tell which one they're looking at.
comment on [Training] three full-body sessions a week through the whole cut in c/glp1muscle · 1 points · 4 days ago
lean mass retention is the 90 week conversation
comment on [Question] small molecule means purity testing is a different problem, right in c/orforglipron · 50 points · 4 days ago
Retitled to remove editorialising. Put the evidence in the body.
comment on why is nobody talking about the SURPASS-CVOT readout in c/tirzepatide · 26 points · 5 days ago
Hard agree. The food noise disappears differently on the two compounds.
comment on why is nobody talking about the SURPASS-CVOT readout in c/tirzepatide · 81 points · 5 days ago
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
comment on [Trial Data] phase 2 biopsy endpoints, and what "resolution" means in c/survodutide · 36 points · 5 days ago
Flair changed to match the content. Read the sidebar before posting next time and we are square.
comment on [Trial Data] phase 2 biopsy endpoints, and what "resolution" means in c/survodutide · 66 points · 5 days ago
not approved, descriptive posts only
comment on [Paper] receptor distribution and why the GI effects were predictable in c/glp1science · 16 points · 6 days ago
Flair changed to match the content. Read the sidebar before posting next time and we are square.
comment on the week 8 version of this is different from the week 4 wall and I don’t think enough people separate them in c/maintenancephase · 17 points · 8 days ago
pharmacologically this also lines up with steady-state timing after a dose step, roughly makes sense that a later stall reflects the drug level itself having settled rather than early noise
comment on GIP agonism explained like i am five, please in c/tirzepatide · 80 points · 9 days ago
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
comment on [Private Plan] my plan added a lifetime maximum halfway through my year in c/glp1canada · 11 points · 9 days ago
Strongly agree. Provincial variation is real.
comment on [Discussion] FFMI not weight, or you will celebrate losing muscle in c/glp1muscle · 8 points · 9 days ago
no supplement selling, no coaching solicitation
comment on [Long Term] found my lowest effective dose by going down, not up in c/maintenancephase · 74 points · 11 days ago
regain after taper is expected, plan for it
comment on the nausea profile at 7.5 was worse than 10 for me and i cannot explain it in c/tirzepatide · 61 points · 12 days ago
Tried both. Sema worked, tirz worked better for me, but my nausea profile was worse on tirz.
comment on [Caution] hepatic endpoints need biopsy data, not an ALT screenshot in c/survodutide · 37 points · 12 days ago
Phase 23 or 35?
comment on [Caution] hepatic endpoints need biopsy data, not an ALT screenshot in c/survodutide · 8 points · 12 days ago
Flair changed to match the content. Read the sidebar before posting next time and we are square.
comment on [Training] kept my deadlift, lost the belly, ate a lot of chicken in c/glp1muscle · 6 points · 14 days ago
resistance training is sarcopenia not optional