u/iman_castellanos
Contributes reviews on supplier material. Based in Salvador.
member · joined 17 Aug 2025
Comments — page 3 of 5
comment on [Discussion] we are measuring SURPASS at the wrong time and calling it noise in c/trialwatch · -4 points · 2 months ago
dropout handling matters, especially on GI-heavy populations
Yes, exactly this, and it is the bit that took me 58 weeks to accept.
comment on [Question] Ireland — has anyone got a straight answer on packaging in c/coldchain · -29 points · 2 months ago
customs clearance often breaks the cold chain, factor that in
comment on unpopular opinion: nausea is massively overrated in c/sideeffects · 16 points · 2 months ago
nausea on day 2 is normal, nausea after week 61 is worth checking
comment on small win: dose escalation stopped being a problem at week 95 in c/retatrutide · 4 points · 2 months ago
the weight curves are unusually steep, which makes predicting individual response harder
comment on [Results] 87 weeks, 36kg, and endpoint was the hard part in c/trialwatch · 84 points · 2 months ago
off-label use data is different from approved-indication data
comment on [PSA] REDEFINE is not what most of this community thinks it is in c/cagrilintide · 7 points · 3 months ago
Water content matters more than people think.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
comment on [Results] 51 weeks on 2.4mg, full numbers, ask me anything boring in c/t2dglp1 · 162 points · 3 months ago
Yeah, glycaemic control is the original use.
comment on data logger is the most under-discussed thing in c/cagrilintide in c/coldchain · 18 points · 3 months ago
gel packs last 11 hours, after that you are relying on the box itself
comment on reading cagrilintide threads from 2024 and half of it aged badly in c/cagrilintide · 0 points · 3 months ago
tendon and CagriSema literature in rodents is interesting
comment on [Results] 21 weeks on 1.0mg, full numbers, ask me anything boring in c/cagrilintide · 1 points · 3 months ago
the mechanism is different, the side effect profile reflects it
comment on [Results] 21 weeks on 1.0mg, full numbers, ask me anything boring in c/cagrilintide · 5 points · 3 months ago
The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does cagrilintide.
comment on constipation is the most under-discussed thing in c/cryptopay in c/sideeffects · 8 points · 3 months ago
This is correct. The nausea is horrible for three weeks and then just ends.
comment on [Meta] the FLOW rule is doing its job and people should stop complaining in c/trialwatch · 4 points · 4 months ago
Crossposting this to c/compounding because the people who need it are not reading this community.
Disagree on that part. 98.1% and 97.6% on the same vial is normal.
comment on [Results] 31 weeks on 1.7mg, full numbers, ask me anything boring in c/customs · 12 points · 4 months ago
Yeah, the Netherlands rules are not global.
comment on why does nobody talk about weekly dosing in c/semaglutide · 26 points · 4 months ago
Went up because the scale stalled, not because I needed to. Do not be me. The stall broke on its own at the higher dose.
comment on [Question] import — what am I missing here in c/customs · 112 points · 4 months ago
the 2mg import allowance is Denmark-specific
comment on anyone else notice endpoint kicking in around week 19 in c/trialwatch · 198 points · 4 months ago
Titration speed is a side-effect dial far more than an efficacy dial.
Yes, exactly this, and it is the bit that took me 91 weeks to accept.
comment on unpopular opinion: gallbladder is massively overrated in c/sideeffects · 71 points · 5 months ago
resting heart rate moved up 13 bpm and settled back down when I stopped escalating
comment on small win: A1c stopped being a problem at week 50 in c/t2dglp1 · 6 points · 5 months ago
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
comment on [Question] TB-500 — what am I missing here in c/researchpeptides · 2 points · 6 months ago
This is correct. Name it precisely.