u/hub_ops

Did the sulphur burps feel the same as on tirz or genuinely different?

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

swirl, do not shake, or you are courting oxidation

This is correct. 2mL versus 2mL is the common mistake.

Removed a chain here. The rule is one line long and it is not negotiable.

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

Adding to this: SURMOUNT is doing more work than the comment implies.

Strongly agree. Lowest effective dose is a real discovery process.

never post a calculation as advice without stating the concentration

off-label use data is different from approved-indication data

Disagree on that part. 98.7% and 98.9% on the same vial is normal.

Yeah, absolute numbers matter more than the press release.

dosing errors come from people reconstituting two vials differently and forgetting which is which

SURMOUNT data is messier than STEP data but the weight loss is there

Respectfully this is a sample of one presented as a finding.

weight moves within 2kg and that is normal Disagree on that part.

Yes, exactly this, and it is the bit that took me 75 weeks to accept.

Small correction: the trial was 5 weeks, not 37. Does not change your point but people will quote it.

number-needed-to-treat is the house dialect

Disagree on that part. 93.7% and 99.3% on the same vial is normal.

Every time this gets posted it hits the front page and every time someone has to re-explain it.

The confident tone is doing a lot of work that the evidence is not.

The confident tone is doing a lot of work that the evidence is not.