u/hedda_aguirre

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

[deleted]

Adding to this: batch is doing more work than the comment implies.

The plateau is real and boring.

Yes, exactly this, and it is the bit that took me 62 weeks to accept.

moderation appeals go through modmail first

the UK plan: step therapy required 20 medications first. Did them all, got approval. The order matters.

Denied for prior auth, resubmitted with prior authorization documentation, approved on appeal. The criteria exist, you just have to meet them.

Denied for prior auth, resubmitted with formulary documentation, approved on appeal. The criteria exist, you just have to meet them.

nobody posts about this part and it is the longest part

Strongly agree. Step therapy is predictable if you have the criteria.

private plans vary by employer

Removed a chain here.

Adding to this: formulary is doing more work than the comment implies.

not approved anywhere, keep posts descriptive, not instructional

This is correct. Weight variance is normal at maintenance.

Strongly agree. Provincial variation is real.

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

Are we talking amylin or GLP-1 here?

the evidence standards are rules

Disagree on that part. 95.1% and 98.4% on the same vial is normal.

below-spec results get logged, not dismissed

the mechanism is different, the side effect profile reflects it

Slight fix: the number was 96.8, not 99.1. Decimal point, but a fairly consequential one.