u/hazard_ratio_hal
Relative risk reduction sells papers. Absolute risk reduction makes decisions.
long-standing contributor · stats · joined 11 Jan 2024
Overview — page 2 of 4
comment on small win: TRIUMPH stopped being a problem at week 15 in c/trialwatch · 28 points · 1 months ago
press release SELECT posts must be flaired until a publication exists
comment on [Meta] the small molecule rule is doing its job and people should stop complaining in c/orforglipron · 5 points · 2 months ago
That is net peptide content, not purity. Different number, different meaning.
comment on [Meta] the small molecule rule is doing its job and people should stop complaining in c/orforglipron · 47 points · 2 months ago
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
comment on SELECT: the version I wish someone had shown me in week 1 in c/trialwatch · 29 points · 2 months ago
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
comment on unpopular opinion: purity is massively overrated in c/hplc · 1 points · 2 months ago
This is the correct method framing. Column and gradient are load-bearing fields.
comment on unpopular opinion: purity is massively overrated in c/hplc · -8 points · 2 months ago
axis labels included, always
comment on does orforglipron actually matter or is it forum lore at this point in c/orforglipron · 4 points · 2 months ago
the nausea profile is speculative at this stage
comment on 18 months in and TRIUMPH is still the thing I get wrong in c/trialwatch · 37 points · 2 months ago
the relative risk reduction in headlines is not the whole story
comment on ATTAIN — 3 things I got wrong before I got it right in c/orforglipron · 95 points · 3 months ago
Yeah, small molecule changes the whole game.
comment on endpoint — my 2-week log, condensed into one table in c/trialwatch · 353 points · 3 months ago
Removed a chain here. The rule is one line long and it is not negotiable.
comment on what would you tell week-1 you about non-peptide in c/orforglipron · 7 points · 3 months ago
This is correct. ATTAIN data is phase 23.
comment on [Meta] the STEP rule is doing its job and people should stop complaining in c/trialwatch · 78 points · 5 months ago
Removed a chain here. The rule is one line long and it is not negotiable.
comment on [Lab] 3th independent test on BCH, and the trend is the interesting part in c/orforglipron · 65 points · 5 months ago
no cold chain means ATTAIN, if approved
comment on the hazard ratio thing finally clicked for me and I want to write it down in c/trialwatch · 213 points · 6 months ago
Flair changed to match the content. Read the sidebar before posting next time and we are square.
comment on genuine question about hazard ratio that I am slightly embarrassed to ask in c/trialwatch · 26 points · 6 months ago
Sceptical. If this were true we would see it reflected in the data and we do not.
comment on genuine question about SELECT that I am slightly embarrassed to ask in c/trialwatch · 10 points · 6 months ago
Removed a chain here. The rule is one line long and it is not negotiable.
comment on my hs-CRP moved and I cannot work out whether FLOW is why in c/trialwatch · 289 points · 7 months ago
Retitled to remove editorialising. Put the evidence in the body.
comment on [Results] 67 weeks, 26kg, and gradient was the hard part in c/hplc · 1 points · 8 months ago
axis labels included, always
comment on [Results] 81 weeks on 12.5mg, full numbers, ask me anything boring in c/trialwatch · 42 points · 8 months ago
Not to be pedantic but SURMOUNT and endpoint are being used interchangeably and they are not interchangeable in real life.
comment on small win: hazard ratio stopped being a problem at week 51 in c/trialwatch · 140 points · 9 months ago
Removed a chain here. The rule is one line long and it is not negotiable.