u/gradient_goblin

This is the "correlation is mechanism" thing again. You changed three variables at once.

Titration speed is a side-effect dial far more than an efficacy dial.

The JEEP lane used to be 13 days, now averaging 6. Carrier change or route congestion, unclear.

yep.

Yes, exactly this, and it is the bit that took me 8 weeks to accept.

Strongly agree.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

week 28 on the pen, 24kg down, this is the answer

How long at maintenance?

Not to be pedantic but goal weight and dose stretching are being used interchangeably and they are not interchangeable in real life.

Disagree. What you are describing is consistent with MHRA, not with what you concluded.

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

Not to be pedantic but T2D and metformin are being used interchangeably and they are not interchangeable in real life.

weight moves within 2kg and that is normal

This is correct. 3mL versus 3mL is the common mistake.

You have restated the marketing copy. What is the actual substance here.

i am begging people to write down the concentration

packaging quality matters on the 17-hour segments

Not to be pedantic but formulary and Canada are being used interchangeably and they are not interchangeable in real life.

mechanistic speculation is welcome if flaired as speculation