1.9k
tried STEP for 14 weeks. here is what happened.
STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the…
u/first_hundred
Member #63. The c/coa rules were my idea and I regret nothing.
long-standing contributor · joined 19 Aug 2023
9,412post karma
10,815comment karma
7submissions
95comments
Overview — page 3 of 5
comment on nobody warned me about nausea and I would have liked the warning in c/coa · 567 points · 5 months ago
Flair changed to match the content. Read the sidebar before posting next time and we are square.
comment on [Vendor] WXT order #6 — the Netherlands, 31 days, no drama, receipts inside in c/trialwatch · 85 points · 5 months ago
Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.
comment on [Lab] SGN BPC — VendorInvestigate came back 93.7% against a claimed 94.2% in c/coa · 364 points · 6 months ago
the counterion is part of the mass you paid for
comment on the Netherlands: purity, and what it actually costs here in c/hplc · 83 points · 6 months ago
integration decision on a shoulder changes your number by half a point on its own
comment on LC-MS: what the trials say vs what this community says in c/hplc · 7 points · 6 months ago
chromatogram or it did not happen
comment on tried STEP for 14 weeks. here is what happened. in c/trialwatch · 13 points · 7 months ago
SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.
comment on tried STEP for 14 weeks. here is what happened. in c/trialwatch · 33 points · 7 months ago
Strongly agree. Phase 2 is investigational, not conclusive.
comment on [Question] New Zealand — has anyone got a straight answer on LC-MS in c/hplc · -14 points · 7 months ago
integration decision on a shoulder changes your number by half a point on its own
comment on COA vs purity — genuinely asking which matters more in c/coa · 374 points · 8 months ago
Disagree. What you are describing is consistent with certificate of analysis, not with what you concluded.
comment on hazard ratio: the version I wish someone had shown me in week 1 in c/trialwatch · 2 points · 8 months ago
Strongly agree. Phase 2 is investigational, not conclusive.
comment on reading SURPASS threads from 2024 and half of it aged badly in c/trialwatch · 103 points · 8 months ago
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
comment on the Netherlands: area percent, and what it actually costs here in c/coa · 112 points · 8 months ago
I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.
comment on the Netherlands: area percent, and what it actually costs here in c/coa · 14 points · 8 months ago
Removed a chain here. The rule is one line long and it is not negotiable.
comment on week 56 check-in — 12kg down, injection-site soreness manageable, one thing confusing me in c/coa · 61 points · 9 months ago
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
comment on [Discussion] the related substances advice in here is 9 years out of date in c/coa · 16 points · 9 months ago
post the whole document, not the headline number
comment on small win: hazard ratio stopped being a problem at week 51 in c/trialwatch · 76 points · 9 months ago
the 3 week readout is different from the 21 week readout
comment on does area percent actually matter or is it forum lore at this point in c/coa · 7 points · 10 months ago
The COA I was holding said 96.8% area and I thought it was trash. Turns out the method was solid and the impurity profile was clean.
comment on genuine question about gradient that I am slightly embarrassed to ask in c/hplc · 1 points · 10 months ago
the detector wavelength matters more than people think
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does area percent actually matter or is it forum lore at this point
Posting this because I searched for it and got nothing useful. Setup: 1.0mg, week 69, constipation present but not ruining anything. I changed exactly one variable —…