u/endpoint_creep
If the primary endpoint changed mid-trial, say so in the abstract.
member · joined 20 Jan 2025
comment on [Failure] 61.2% purity on a vial i had already been using for six weeks in c/darkspot · -6 points · 6 days ago
Strongly agree. No piling on.
comment on [Discussion] we talk about dose like it is a score and it is not in c/semaglutide · 7 points · 26 days ago
Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule
comment on sunday night injection, 61 weeks straight, ask me anything boring in c/semaglutide · 1 points · 26 days ago
week 87 and i am still not at maintenance, do not rush the ladder
comment on went back down from 2.4 to 1.7 and lost more. explain that in c/semaglutide · 1 points · 1 months ago
Small correction: the trial was 14 weeks, not 9. Does not change your point but people will quote it.
comment on went back down from 2.4 to 1.7 and lost more. explain that in c/semaglutide · 56 points · 1 months ago
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
comment on [Failure] two years in, stopped for financial reasons, regained most of it in c/darkspot · 15 points · 1 months ago
the lesson is the point
comment on [Meta] the 15mg rule is doing its job and people should stop complaining in c/tirzepatide · 38 points · 1 months ago
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
comment on someone explain plateau to me like I have not read a paper in years in c/semaglutide · 18 points · 1 months ago
week 63 and i am still not at maintenance, do not rush the ladder
comment on [PSA] Medutest results are area% by default and people keep forgetting in c/tirzepatide · 284 points · 1 months ago
the early fullness from tirz is different, not necessarily worse
Disagree on that part. 99.3% and 93.7% on the same vial is normal.
comment on [Question] how do you actually verify below spec in c/darkspot · 31 points · 1 months ago
comment on small win: GIP stopped being a problem at week 31 in c/tirzepatide · 39 points · 1 months ago
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
comment on does lost money actually matter or is it forum lore at this point in c/darkspot · 2 points · 2 months ago
Disagree but this is the good kind of wrong — it is specific enough to be checked.
comment on week 16 check-in — 17kg down, fatigue manageable, one thing confusing me in c/semaglutide · 1 points · 2 months ago
my triglycerides moved before the scale did and i nearly missed it
comment on switched from 1.0mg to 2.5mg and the the food-noise thing got better, not worse in c/tirzepatide · 0 points · 2 months ago
the 15mg is the top of the pen, not the required dose
comment on anyone else notice lost money kicking in around week 80 in c/darkspot · 1 points · 2 months ago
money lost to group buys
comment on week 51 check-in — 26kg down, fatigue manageable, one thing confusing me in c/semaglutide · 5 points · 2 months ago
Right, and the corollary is that stopping escalation does not reset your tolerance, it just pauses the clock.
comment on [Question] regret — what am I missing here in c/darkspot · 1 points · 3 months ago
the lesson is the point
comment on titration — 20 things I got wrong before I got it right in c/semaglutide · 1 points · 3 months ago
week 91 and i am still not at maintenance, do not rush the ladder
comment on [Lab] split one vial across Medutest and Janoshik — 96.2% and 97.4% in c/semaglutide · 1 points · 6 months ago
the injection-site soreness passes. i promise. not medical advice.
comment on does 2.4mg actually matter or is it forum lore at this point in c/semaglutide · 845 points · 6 months ago
titration speed is titration plus side effects, period