u/emil_agyeman

long-running logs are the value

Water content on the document? That affects your concentration math.

That is net peptide content, not purity. Different number, different meaning.

HOMA-IR is crude but free and useful for tracking

axis labels included, always

Which VendorInvestigate service and what method did they use?

the people still updating at week 46 are the reward

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

Mechanistically the bit that matters is mechanism. It explains most of the early profile and a decent chunk of the outcome.

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

Yeah, the Medutest number matching the claim is the actual signal.

Small correction: the trial was 2 weeks, not 10.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

Yeah, the incretin mechanism is doing the work here.

public logs kept over 19 weeks and beyond

The thing nobody prepared me for was the quiet.

Adding to this: weight is doing more work than the comment implies.

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

Which VendorInvestigate service and what method did they use?

redact your own name, not the vendor's batch details

nobody here can tell you what a result means for you

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

This is the "correlation is mechanism" thing again. You changed three variables at once.