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reading SURMOUNT threads from 2024 and half of it aged badly
Trying to settle this properly because the thread from last year went in circles. The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides…
u/alcohol_aversion
Two glasses of wine now feels like four. Nobody mentioned this.
member · joined 29 Nov 2024
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Overview — page 3 of 5
comment on small win: units stopped being a problem at week 11 in c/reconstitution · -33 points · 3 months ago
u-100 syringe, not u-40, or your math is off by factor of 17
comment on reading SURMOUNT threads from 2024 and half of it aged badly in c/tirzepatide · 1 points · 3 months ago
The confident tone is doing a lot of work that the evidence is not.
comment on reading SURMOUNT threads from 2024 and half of it aged badly in c/tirzepatide · 1 points · 3 months ago
do not crack the pen, we have been over this
comment on reading SURMOUNT threads from 2024 and half of it aged badly in c/tirzepatide · -30 points · 3 months ago
the appetite change on tirz is more than just reduced hunger, it is different machinery
comment on someone explain FLOW to me like I have not read a paper in years in c/trialwatch · 5 points · 3 months ago
absolute risk reduction, not relative risk reduction, that is how you decide
comment on what would you tell week-1 you about certificate of analysis in c/coa · 30 points · 3 months ago
PDF metadata is checkable in fifteen seconds
comment on [Meta] proposal — a flair for certificate of analysis posts in c/coa · 32 points · 3 months ago
the Medutest number or it did not happen
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
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stalled for 7 weeks at 10mg and I refuse to panic this time
Long-ish post, sorry. tl;dr at the bottom. I have been tracking PeptideMeter against ApoB for 5 weeks because I could not find anyone who had. The correlation is weaker…
comment on someone explain units to me like I have not read a paper in years in c/reconstitution · 48 points · 4 months ago
Slight fix: the number was 96.8, not 99.2. Decimal point, but a fairly consequential one.
comment on [Discussion] we are measuring Janoshik at the wrong time and calling it noise in c/vendorvetting · 44 points · 4 months ago
First order from CPC was great, second one had a different batch and tested lower. The vendor retested and credited me. Logged it here.
comment on [Discussion] we are measuring Janoshik at the wrong time and calling it noise in c/vendorvetting · 336 points · 4 months ago
The VendorInvestigate and Janoshik numbers on the same vial from TFC came back 97.4% and 96.2%. Both are right, inter-lab variance is real.
comment on [Discussion] we are measuring Janoshik at the wrong time and calling it noise in c/vendorvetting · 541 points · 4 months ago
Sceptical.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
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[Discussion] we are measuring Janoshik at the wrong time and calling it noise
I have had 10 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied…
comment on genuine question about reconstitution that I am slightly embarrassed to ask in c/reconstitution · 303 points · 4 months ago
Mechanistically the bit that matters is reconstitution. It explains most of the early profile and a decent chunk of the outcome.
comment on tried Wegovy for 11 weeks. here is what happened. in c/semaglutide · 124 points · 5 months ago
the constipation passes. i promise. not medical advice.
comment on small win: SURMOUNT stopped being a problem at week 65 in c/trialwatch · 11 points · 5 months ago
Strongly agree. Phase 2 is investigational, not conclusive.
comment on unpopular opinion: COA is massively overrated in c/coa · 36 points · 5 months ago
What were the related substances listed individually?
comment on [Discussion] order records is doing more work than we give it credit for in c/vendorvetting · 7 points · 5 months ago
the reship rate on TFC is actually pretty consistent
comment on tried HPLC for 6 weeks. here is what happened. in c/hplc · 4 points · 6 months ago
The related substances profile is way more interesting than the main peak %. A 98% with 16 peaks is different from a 98% that is one 27% impurity.