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u/alcohol_aversion

Two glasses of wine now feels like four. Nobody mentioned this.

member · joined 29 Nov 2024

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Comments — page 3 of 5

comment on reading SURMOUNT threads from 2024 and half of it aged badly in c/tirzepatide · -30 points · 3 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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comment on someone explain FLOW to me like I have not read a paper in years in c/trialwatch · 5 points · 3 months ago

absolute risk reduction, not relative risk reduction, that is how you decide

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comment on what would you tell week-1 you about certificate of analysis in c/coa · 30 points · 3 months ago

PDF metadata is checkable in fifteen seconds

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comment on [Meta] proposal — a flair for certificate of analysis posts in c/coa · 32 points · 3 months ago

the Medutest number or it did not happen

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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comment on someone explain units to me like I have not read a paper in years in c/reconstitution · 48 points · 4 months ago

Slight fix: the number was 96.8, not 99.2. Decimal point, but a fairly consequential one.

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comment on [Discussion] we are measuring Janoshik at the wrong time and calling it noise in c/vendorvetting · 44 points · 4 months ago

First order from CPC was great, second one had a different batch and tested lower. The vendor retested and credited me. Logged it here.

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comment on [Discussion] we are measuring Janoshik at the wrong time and calling it noise in c/vendorvetting · 336 points · 4 months ago

The VendorInvestigate and Janoshik numbers on the same vial from TFC came back 97.4% and 96.2%. Both are right, inter-lab variance is real.

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comment on [Discussion] we are measuring Janoshik at the wrong time and calling it noise in c/vendorvetting · 541 points · 4 months ago

Sceptical.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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comment on genuine question about reconstitution that I am slightly embarrassed to ask in c/reconstitution · 303 points · 4 months ago

Mechanistically the bit that matters is reconstitution. It explains most of the early profile and a decent chunk of the outcome.

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comment on tried Wegovy for 11 weeks. here is what happened. in c/semaglutide · 124 points · 5 months ago

the constipation passes. i promise. not medical advice.

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comment on small win: SURMOUNT stopped being a problem at week 65 in c/trialwatch · 11 points · 5 months ago

Strongly agree. Phase 2 is investigational, not conclusive.

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comment on unpopular opinion: COA is massively overrated in c/coa · 36 points · 5 months ago

What were the related substances listed individually?

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comment on [Discussion] order records is doing more work than we give it credit for in c/vendorvetting · 7 points · 5 months ago

the reship rate on TFC is actually pretty consistent

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comment on tried HPLC for 6 weeks. here is what happened. in c/hplc · 4 points · 6 months ago

The related substances profile is way more interesting than the main peak %. A 98% with 16 peaks is different from a 98% that is one 27% impurity.

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comment on tried HPLC for 6 weeks. here is what happened. in c/hplc · 13 points · 6 months ago

Detection wavelength? chromatogram and that changes at different wavelengths.

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comment on protein is the most under-discussed thing in c/cagrilintide in c/glp1muscle · 17 points · 6 months ago

Yeah, protein matters on rapid loss.

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comment on tried HPLC for 6 weeks. here is what happened. in c/hplc · 0 points · 6 months ago

Detection wavelength? integration and that changes at different wavelengths.

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comment on [Lab] split one vial across Medutest and Janoshik — 96.2% and 97.4% in c/semaglutide · 0 points · 6 months ago

Yeah, 47 weeks on 0.5mg, same pattern, same timing.

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comment on [PSA] Medutest is not what most of this community thinks it is in c/vendorvetting · 1 points · 6 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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comment on 4 months in and dead space is still the thing I get wrong in c/reconstitution · 69 points · 6 months ago

i am begging people to write down the concentration

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