Something I noticed reading old threads that I have not seen said out loud. The advice on gradient in this community changed substantially around the start of last…
method development
Every GLP Research Hub submission tagged to method development, ranked by score. Discussed in 1 community.
chromatogram. That is the whole post, but I will justify it. Everything else people worry about in c/reconstitution is downstream of it. Titration speed, muscle cramps,…
Confession thread, sort of. I went from 0.25mg to 10mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 22 weeks…
Right, the purity question again, but with numbers this time. I have 5 data points over 10 weeks. The pattern is consistent enough that I do not think it is chance, and…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standardsBeen lurking in c/t2dglp1 for about 16 months and finally have something worth posting. Short version: week 72, 10mg, and LC-MS is the bit I still cannot get a straight…
Quick one. Canada here. integration works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given…
Something I noticed reading old threads that I have not seen said out loud. The advice on chromatogram in this community changed substantially around the start of last…
chromatogram. That is the whole post, but I will justify it. Everything else people worry about in c/dosinglogs is downstream of it. Titration speed, early fullness,…
Week 16 update. 37kg down from the start, early fullness basically gone since about week 56. Things that worked: consistency, protein at breakfast, walking more than I…
Something I noticed reading old threads that I have not seen said out loud. The advice on LC-MS in this community changed substantially around the start of last year,…
Genuinely asking, not being difficult. Everyone in c/glp1uk repeats that method development is important. I believe it, but I have never seen anyone show why, and when…
method development. That is the whole post, but I will justify it. Everything else people worry about in c/dosinglogs is downstream of it. Titration speed, reflux, the…
Confession thread, sort of. I went from 2.4mg to 0.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 19 weeks…
Long-ish post, sorry. tl;dr at the bottom. I have been tracking method development against triglycerides for 25 weeks because I could not find anyone who had. The…
Genuinely asking, not being difficult. Everyone in c/glp1uk repeats that HPLC is important. I believe it, but I have never seen anyone show why, and when I search I get…
Janoshik Analytical — independent HPLC & mass spec
Send the vial, get the number. Third-party purity and identity testing, results published to you regardless of what they say.
Test a vialSponsoredGL Biochem (Shanghai) Ltd. — the synthesis house
Est. 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. There is a fair chance the vial you are about to send for testing started here. Batch-specific COA as standard.
glbiochem.netSomething I noticed reading old threads that I have not seen said out loud. The advice on integration in this community changed substantially around the start of last…
Posting this because I searched for it and got nothing useful. Setup: 5mg, week 26, sulphur burps present but not ruining anything. I changed exactly one variable —…
Week 47 update. 43kg down from the start, reflux basically gone since about week 87. Things that worked: consistency, protein at breakfast, walking more than I want to.…
Long-ish post, sorry. tl;dr at the bottom. I have been tracking LC-MS against eGFR for 29 weeks because I could not find anyone who had. The correlation is weaker than…
Right, the purity question again, but with numbers this time. I have 12 data points over 32 weeks. The pattern is consistent enough that I do not think it is chance,…
chromatogram. That is the whole post, but I will justify it. Everything else people worry about in c/dosinglogs is downstream of it. Titration speed, muscle cramps, the…
Been lurking in c/t2dglp1 for about 13 months and finally have something worth posting. Short version: week 34, 15mg, and gradient is the bit I still cannot get a…
method development. That is the whole post, but I will justify it. Everything else people worry about in c/dosinglogs is downstream of it. Titration speed, early…
Right, the HPLC question again, but with numbers this time. I have 15 data points over 40 weeks. The pattern is consistent enough that I do not think it is chance, and…
Genuinely asking, not being difficult. Everyone in c/glp1uk repeats that method development is important. I believe it, but I have never seen anyone show why, and when…