298
reading STEP threads from 2024 and half of it aged badly
Trying to settle this properly because the thread from last year went in circles. The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have…
FLOW
Every GLP Research Hub submission tagged to FLOW, ranked by score. Discussed in 1 community.
Communities covering this
287
FLOW got published and nobody in here is talking about eGFR slope
Quick one. Canada here. endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
247
[Discussion] can we stop arguing about STEP until somebody posts a number
STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the…
233
intent-to-treat vs per-protocol explains half the arguments on this site
Trying to settle this properly because the thread from last year went in circles. The claim: STEP matters. The counter-claim: it is measurement error. Both sides have…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standards191
help me understand FLOW, I have read the wiki twice
FLOW. That is the whole post, but I will justify it. Everything else people worry about in c/coa is downstream of it. Titration speed, reflux, the endless dose…
183
genuine question about SELECT that I am slightly embarrassed to ask
Week 45 update. 16kg down from the start, reflux basically gone since about week 85. Things that worked: consistency, protein at breakfast, walking more than I want to.…
155
[Discussion] the SURPASS advice in here is 8 years out of date
Right, the TRIUMPH question again, but with numbers this time. I have 14 data points over 40 weeks. The pattern is consistent enough that I do not think it is chance,…
144
SURMOUNT: what the trials say vs what this community says
Something I noticed reading old threads that I have not seen said out loud. The advice on SURMOUNT in this community changed substantially around the start of last…
103
someone explain FLOW to me like I have not read a paper in years
Quick one. Canada here. endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
95
[Readout] SELECT: MACE HR 0.80, and the absolute numbers people skip
Right, the TRIUMPH question again, but with numbers this time. I have 8 data points over 28 weeks. The pattern is consistent enough that I do not think it is chance,…
95
what would you tell week-1 you about SELECT
Confession thread, sort of. I went from 1.7mg to 0.25mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 3 weeks…
94
[Meta] the FLOW rule is doing its job and people should stop complaining
STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the…
79
genuine question about SURMOUNT that I am slightly embarrassed to ask
Confession thread, sort of. I went from 7.5mg to 2.4mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 6 weeks…
77
[Lab] 14th independent test on BCH, and the trend is the interesting part
I have had 2 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied…
58
[Vendor] QST order #6 — Denmark, 5 days, no drama, receipts inside
Trying to settle this properly because the thread from last year went in circles. The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have…
Janoshik Analytical — independent HPLC & mass spec
Send the vial, get the number. Third-party purity and identity testing, results published to you regardless of what they say.
Test a vialSponsoredGL Biochem (Shanghai) Ltd. — the synthesis house
Est. 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. There is a fair chance the vial you are about to send for testing started here. Batch-specific COA as standard.
glbiochem.net-31
week 91 check-in — 37kg down, early fullness manageable, one thing confusing me
Week 14 update. 10kg down from the start, early fullness basically gone since about week 54. Things that worked: consistency, protein at breakfast, walking more than I…
-35
the FLOW question that gets asked weekly, answered properly
STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, early fullness, the…
-38
hazard ratio: the version I wish someone had shown me in week 1
Quick one. Canada here. endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
-47
[Results] 12 weeks, 35kg, and FLOW was the hard part
Posting this because I searched for it and got nothing useful. Setup: 7.5mg, week 63, injection-site soreness present but not ruining anything. I changed exactly one…
-59
FLOW got published and nobody in here is talking about eGFR slope
FLOW (Perkovic et al., N Engl J Med , 2024) reported a hazard ratio of 0.76 for the composite kidney endpoint in people with type 2 diabetes and chronic kidney disease.…