305
[Paper] SURMOUNT-4 withdrawal arm, read the appendix not the abstract
Trying to settle this properly because the thread from last year went in circles. The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have…
endpoint
Every GLP Research Hub submission tagged to endpoint, ranked by score. Discussed in 1 community.
Communities covering this
298
reading STEP threads from 2024 and half of it aged badly
Trying to settle this properly because the thread from last year went in circles. The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have…
287
FLOW got published and nobody in here is talking about eGFR slope
Quick one. Canada here. endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
266
[Caution] hepatic endpoints need biopsy data, not an ALT screenshot
Confession thread, sort of. I went from 1.0mg to 15mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 17 weeks…
PeptideMeter — community peptide analytics
Vendor-level purity averages over time, built from independent results rather than vendor claims. Transparent methodology, open dataset.
Browse results247
[Discussion] can we stop arguing about STEP until somebody posts a number
STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the…
233
intent-to-treat vs per-protocol explains half the arguments on this site
Trying to settle this properly because the thread from last year went in circles. The claim: STEP matters. The counter-claim: it is measurement error. Both sides have…
191
help me understand FLOW, I have read the wiki twice
FLOW. That is the whole post, but I will justify it. Everything else people worry about in c/coa is downstream of it. Titration speed, reflux, the endless dose…
183
genuine question about SELECT that I am slightly embarrassed to ask
Week 45 update. 16kg down from the start, reflux basically gone since about week 85. Things that worked: consistency, protein at breakfast, walking more than I want to.…
155
[Discussion] the SURPASS advice in here is 8 years out of date
Right, the TRIUMPH question again, but with numbers this time. I have 14 data points over 40 weeks. The pattern is consistent enough that I do not think it is chance,…
144
SURMOUNT: what the trials say vs what this community says
Something I noticed reading old threads that I have not seen said out loud. The advice on SURMOUNT in this community changed substantially around the start of last…
103
someone explain FLOW to me like I have not read a paper in years
Quick one. Canada here. endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
95
[Readout] SELECT: MACE HR 0.80, and the absolute numbers people skip
Right, the TRIUMPH question again, but with numbers this time. I have 8 data points over 28 weeks. The pattern is consistent enough that I do not think it is chance,…
95
what would you tell week-1 you about SELECT
Confession thread, sort of. I went from 1.7mg to 0.25mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 3 weeks…
94
[Meta] the FLOW rule is doing its job and people should stop complaining
STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the…
79
genuine question about SURMOUNT that I am slightly embarrassed to ask
Confession thread, sort of. I went from 7.5mg to 2.4mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 6 weeks…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standards77
[Lab] 14th independent test on BCH, and the trend is the interesting part
I have had 2 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied…
58
[Vendor] QST order #6 — Denmark, 5 days, no drama, receipts inside
Trying to settle this properly because the thread from last year went in circles. The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have…
-31
week 91 check-in — 37kg down, early fullness manageable, one thing confusing me
Week 14 update. 10kg down from the start, early fullness basically gone since about week 54. Things that worked: consistency, protein at breakfast, walking more than I…
-35
the FLOW question that gets asked weekly, answered properly
STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, early fullness, the…
-38
hazard ratio: the version I wish someone had shown me in week 1
Quick one. Canada here. endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
-47
[Results] 12 weeks, 35kg, and FLOW was the hard part
Posting this because I searched for it and got nothing useful. Setup: 7.5mg, week 63, injection-site soreness present but not ruining anything. I changed exactly one…
-59
FLOW got published and nobody in here is talking about eGFR slope
FLOW (Perkovic et al., N Engl J Med , 2024) reported a hazard ratio of 0.76 for the composite kidney endpoint in people with type 2 diabetes and chronic kidney disease.…