-64
dual agonist: what the trials say vs what this community says
Right, the Mounjaro question again, but with numbers this time. I have 12 data points over 26 weeks. The pattern is consistent enough that I do not think it is chance,…
Controversial — page 15
Positions 351–375 of 1,000 ranked submissions.
109
[Question] protein target in g/kg — of current weight or goal weight
Long-ish post, sorry. tl;dr at the bottom. I have been tracking lean mass against ApoB for 27 weeks because I could not find anyone who had. The correlation is weaker…
401
[Caution] CagriSema trial ratios are fixed-dose, do not extrapolate to self-mixing
Right, the amylin question again, but with numbers this time. I have 22 data points over 28 weeks. The pattern is consistent enough that I do not think it is chance,…
-50
why does nobody talk about method development
Been lurking in c/t2dglp1 for about 4 months and finally have something worth posting. Short version: week 60, 2.5mg, and method development is the bit I still cannot…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standards-51
someone explain PeptideMeter to me like I have not read a paper in years
Trying to settle this properly because the thread from last year went in circles. The claim: vendor matters. The counter-claim: it is measurement error. Both sides have…
-48
the nausea question that gets asked weekly, answered properly
Genuinely asking, not being difficult. Everyone in c/vendorvetting repeats that fatigue is important. I believe it, but I have never seen anyone show why, and when I…
-50
12 months in and week one is still the thing I get wrong
Posting this because I searched for it and got nothing useful. Setup: 2.4mg, week 86, constipation present but not ruining anything. I changed exactly one variable —…
-11
cored the stopper on day 9. rotate your puncture site
Confession thread, sort of. I went from 0.5mg to 12.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 13 weeks…
647
17 months in and Canada is still the thing I get wrong
Quick one. Canada here. Canada works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
-45
[Vendor] WXT order #19 — Germany, 7 days, no drama, receipts inside
Been lurking in c/retatrutide for about 6 months and finally have something worth posting. Short version: week 7, 1.0mg, and lowest effective dose is the bit I still…
-43
help me understand chromatogram, I have read the wiki twice
I have had 12 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied…
-54
[Lab] 9th independent test on BCH, and the trend is the interesting part
I have had 7 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied…
49
[Private Plan] special authorisation approved on the second try
Genuinely asking, not being difficult. Everyone in c/newbiequestions repeats that formulary is important. I believe it, but I have never seen anyone show why, and when…
-10
my compounded vial arrived at a different concentration than last month
Quick one. Canada here. 503A works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
471
[Discussion] can we stop arguing about T2D until somebody posts a number
Been lurking in c/scamalerts for about 5 months and finally have something worth posting. Short version: week 95, 2.4mg, and A1c is the bit I still cannot get a…
Janoshik Analytical — independent HPLC & mass spec
Send the vial, get the number. Third-party purity and identity testing, results published to you regardless of what they say.
Test a vialSponsoredGL Biochem (Shanghai) Ltd. — the synthesis house
Est. 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. There is a fair chance the vial you are about to send for testing started here. Batch-specific COA as standard.
glbiochem.net-47
[Discussion] the data logger advice in here is 6 years out of date
Right, the ice pack question again, but with numbers this time. I have 5 data points over 38 weeks. The pattern is consistent enough that I do not think it is chance,…
-41
switched from 0.5mg to 2.4mg and the the food-noise thing got better, not worse
Long-ish post, sorry. tl;dr at the bottom. I have been tracking retatrutide against triglycerides for 21 weeks because I could not find anyone who had. The correlation…
-38
hazard ratio: the version I wish someone had shown me in week 1
Quick one. Canada here. endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
-37
someone explain batch to me like I have not read a paper in years
Confession thread, sort of. I went from 1.0mg to 15mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 5 weeks…
-9
switched from 12.5mg to 0.5mg and the fatigue got better, not worse
Trying to settle this properly because the thread from last year went in circles. The claim: compounding matters. The counter-claim: it is measurement error. Both sides…
-32
[Discussion] we are measuring reconstitution at the wrong time and calling it noise
Posting this because I searched for it and got nothing useful. Setup: 10mg, week 23, sulphur burps present but not ruining anything. I changed exactly one variable —…
-31
genuine question about Canada that I am slightly embarrassed to ask
Genuinely asking, not being difficult. Everyone in c/newbiequestions repeats that private plan is important. I believe it, but I have never seen anyone show why, and…
242
[Formulary] provincial differences, mapped, with dates
Right, the special authorization question again, but with numbers this time. I have 4 data points over 4 weeks. The pattern is consistent enough that I do not think it…
388
[Question] small molecule means purity testing is a different problem, right
Week 52 update. 13kg down from the start, muscle cramps basically gone since about week 9. Things that worked: consistency, protein at breakfast, walking more than I…
-35
the FLOW question that gets asked weekly, answered properly
STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, early fullness, the…