STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the…
c/trialwatch — hot, page 4
Positions 76–95 of 95.
Week 73 update. 19kg down from the start, early fullness basically gone since about week 30. Things that worked: consistency, protein at breakfast, walking more than I…
Posting this because I searched for it and got nothing useful. Setup: 0.5mg, week 83, injection-site soreness present but not ruining anything. I changed exactly one…
Right, the TRIUMPH question again, but with numbers this time. I have 5 data points over 38 weeks. The pattern is consistent enough that I do not think it is chance,…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standardsTrying to settle this properly because the thread from last year went in circles. The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have…
Week 55 update. 31kg down from the start, muscle cramps basically gone since about week 95. Things that worked: consistency, protein at breakfast, walking more than I…
Posting this because I searched for it and got nothing useful. Setup: 2.5mg, week 5, constipation present but not ruining anything. I changed exactly one variable —…
Confession thread, sort of. I went from 1.0mg to 15mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 11 weeks…
STEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, muscle cramps, the…
Quick one. Canada here. endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
Something I noticed reading old threads that I have not seen said out loud. The advice on TRIUMPH in this community changed substantially around the start of last year,…
I have had 18 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied…
Quick one. Canada here. endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
Long-ish post, sorry. tl;dr at the bottom. I have been tracking STEP against eGFR for 35 weeks because I could not find anyone who had. The correlation is weaker than I…
Right, the SURMOUNT question again, but with numbers this time. I have 13 data points over 18 weeks. The pattern is consistent enough that I do not think it is chance,…
Janoshik Analytical — independent HPLC & mass spec
Send the vial, get the number. Third-party purity and identity testing, results published to you regardless of what they say.
Test a vialSponsoredGL Biochem (Shanghai) Ltd. — the synthesis house
Est. 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. There is a fair chance the vial you are about to send for testing started here. Batch-specific COA as standard.
glbiochem.netSTEP. That is the whole post, but I will justify it. Everything else people worry about in c/orforglipron is downstream of it. Titration speed, early fullness, the…
Week 14 update. 10kg down from the start, early fullness basically gone since about week 54. Things that worked: consistency, protein at breakfast, walking more than I…
Quick one. Canada here. endpoint works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice…
Posting this because I searched for it and got nothing useful. Setup: 7.5mg, week 63, injection-site soreness present but not ruining anything. I changed exactly one…
FLOW (Perkovic et al., N Engl J Med , 2024) reported a hazard ratio of 0.76 for the composite kidney endpoint in people with type 2 diabetes and chronic kidney disease.…