why does nobody talk about SELECT
Asking properly rather than in a comment on somebody else’s thread: why does nobody talk about SELECT. Compared myself to a trial mean for about six months before realising the trial arm had dietitian contact every fortnight. The discontinuation numbers were the most useful thing in the paper for me and they were in…
Discontinuation rates are a tolerability result. A trial with a strong efficacy number and heavy discontinuation is telling you two things and people only quote one.
Retitled: the original quoted a diabetes endpoint as an obesity result.
Spent an evening with the appendix tables and found the subgroup detail that the entire thread had been speculating about.
Spent an evening with the appendix tables and found the subgroup detail that the entire thread had been speculating about.
Disagreeing with this line: that is a relative reduction and the absolute numbers are considerably less dramatic.
Read a press release and the publication three months apart. The hedging in the second one was substantial.
Is that intention-to-treat or completers?
Same. A press release is a claim about a result; the publication is the result.