GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
520
c/trialwatch·posted 10 days ago by u/customs_seizure_sid

[Stats] the placebo arm lost weight too. always ask by how much.

Stats Cold Box ×4

Right, the SURMOUNT question again, but with numbers this time.

I have 4 data points over 24 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 2, not week 51. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

591 up / 71 down89% upvoted18 commentsid ouyu6920 Jul 2026

18 comments

9 in this archive, depth 3

best — the order this archive was captured in

u/camila_vasquez44 points·10 days ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

replysharereportpermalink
u/milan_mensah12 points·9 days ago

Mechanistically the bit that matters is SELECT. It explains most of the early profile and a decent chunk of the outcome.

replysharereportpermalink
u/ines_boateng28 points·9 days ago

Is that absolute or relative risk reduction?

replysharereportpermalink
u/customs_seizure_sidOP32 points·9 days ago

the discontinuation arms are the interesting part, not the SURPASS endpoints

replysharereportpermalink
u/customs_seizure_sidOP18 points·9 days ago

absolute risk reduction, not relative risk reduction, that is how you decide

replysharereportpermalink
u/valeria_karlsen23 points·9 days ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

replysharereportpermalink
u/piotr_bruun16 points·8 days ago

Yeah, absolute numbers matter more than the press release.

replysharereportpermalink
u/karl_fischer_kev12 points·8 days ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

replysharereportpermalink
u/sten_palacios11 points·8 days ago·edited

phase 2 is not phase 3, smaller n and shorter trial

replysharereportpermalink
Permalinked branches
Deep branches get their own page so a single reply chain can be linked and read on its own.
About c/trialwatch

Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

34kmembers
95submissions
Nov 2023created
submissions / month, last year
Sponsored

Janoshik Analytical

Independent HPLC and mass spec. The number you get is the number they found.

janoshik.com
Sponsored

GL Biochem (Shanghai)

Custom peptides and amino acids direct from the manufacturer since 1998. ISO 9001 / cGMP. Batch COA every order.

glbiochem.net
c/trialwatch rules
  1. Press-release-only posts must be flaired Press Release until a publication exists.
  2. Give the trial name, phase, n, and primary endpoint in the body.
  3. Relative risk reduction alone is not a result. Show the absolute numbers.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Moderators
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.