[Press Release] new phase 3 numbers, no publication yet, calm down
new phase 3 numbers, no publication yet, calm down. It is the sort of thing everyone half-believes and nobody writes down. A confidence interval is the range of effects compatible with the data. Two trials with overlapping intervals have not disagreed, whatever their point estimates look like next to each other.…
Spent an evening with the appendix tables and found the subgroup detail that the entire thread had been speculating about.
check who the comparator was before you compare anything
Do you have the publication or the press release?
Correction: SURMOUNT is the obesity programme and SURPASS is the diabetes one. The figure you quoted belongs to the other one.
That is a relative risk reduction. Quoting it without the absolute numbers overstates the case considerably.
That is a relative risk reduction.
Agreed. And the interval, not the point estimate, is what the trial actually established.
The registered protocol is public. Comparing the registered primary endpoint with the reported one is a two-minute check and it is how outcome switching gets caught.
Small fix — that was the cardiovascular outcomes trial, so weight was a secondary endpoint and the population was different.