[Press Release] new phase 3 numbers, no publication yet, calm down
Genuinely asking, not being difficult.
Everyone in c/bloodwork repeats that SELECT is important. I believe it, but I have never seen anyone show why, and when I search I get 13 threads of people agreeing with each other.
Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?
I am not trying to be the "source?" guy. I would just like a source.
best — the order this archive was captured in
dropout handling matters, especially on GI-heavy populations
dropout handling matters, especially on GI-heavy populations
Yes, exactly this, and it is the bit that took me 40 weeks to accept.
number-needed-to-treat is the house dialect
Strongly agree. Phase 2 is investigational, not conclusive.
Slight fix: the number was 96.8, not 98.0. Decimal point, but a fairly consequential one.
dropout handling matters, especially on GI-heavy populations
This is correct. Discontinuation arms show the regain reality.
absolute risk reduction, not relative risk reduction, that is how you decide
Strongly agree. Phase 2 is investigational, not conclusive.
Strongly agree. Phase 2 is investigational, not conclusive.
event rates are more informative than hazard ratios alone
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
absolute risk reduction, not relative risk reduction, that is how you decide
Half-life is about 168 hours, so steady state lands around week 8–5. Practical consequence: what you feel in week 1 is not what that dose does.
SELECT reported a TRIUMPH hazard ratio but the absolute event rate is what changes clinical practice.
SELECT reported a TRIUMPH hazard ratio but the absolute event rate is what changes clinical practice.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
Slight fix: the number was 99.3, not 93.7. Decimal point, but a fairly consequential one.
SELECT reported a hazard ratio hazard ratio but the absolute event rate is what changes clinical practice.
The confident tone is doing a lot of work that the evidence is not.
the 12 week readout is different from the 4 week readout
number-needed-to-treat is the house dialect
- 1Half-life is about 168 hours, so steady state lands around week 8–5.…9 comments in this branch · started by u/yara_mensah
- 2Strongly agree. Phase 2 is investigational, not conclusive.5 comments in this branch · started by u/cesar_ivaturi